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Role of Cysteine & Glutathione in HIV infection & other diseases associated with muscle wasting & immunological dysfunction
By Droge W, Holm E
G11-15-1997 The combination of abnormally low plasma cysteine and glutamine levels, low natural killer (NK) cell activity, skeletal muscle wasting or muscle fatigue, and increased rates of urea production defines a complex of abnormalities that is tentatively called "low CG syndrome." These symptoms are found in patients with HIV infection, cancer, major injuries, sepsis, Crohn's disease, ulcerative colitis, chronic fatigue syndrome, and to some extent in over trained athletes. The coincidence of these symptoms in diseases of different etiological origin suggests a causal relationship. The low NK cell activity in most cases is not life-threatening, but may be disastrous in HIV infection because it may compromise the initially stable balance between the immune system and virus, and trigger disease progression. This hypothesis is supported by the coincidence observed between the decrease of CD4+ T cells and a decrease in the plasma cysteine level. In addition, recent studies revealed important clues about the role of cysteine and Glutathione in the development of skeletal muscle wasting. Evidence suggests that 1) the cysteine level is regulated primarily by the normal post absorptive skeletal muscle protein catabolism, 2) the cysteine level itself is a physiological regulator of nitrogen balance and body cell mass, 3) the cysteine-mediated regulatory circuit is compromised in various catabolic conditions, including old age, and 4) cysteine supplementation may be a useful therapy if combined with disease-specific treatments such as antiviral therapy in HIV infection.
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